CHESS is a comprehensive set of human genes based on nearly 10,000 RNA sequencing experiments produced by the GTEx project. It includes a total of protein-coding genes and lncRNA genes. Adding antisense and other RNA genes, release of the database contains genes and transcripts. Of these transcripts, represent protein-coding gene isoforms and the rest are noncoding RNAs. The database also contains pseudogenes and corresponding transcripts as well as genes and transcripts annotated on alternative scaffolds of GRCh38.

CHESS data

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Publications

  • Varabyou, A., Sommer, M. J., Erdogdu, B., Shinder, I., Minkin, I., ... & Pertea, M. (2022). CHESS 3: an improved, comprehensive catalog of human genes and transcripts based on large-scale expression data, phylogenetic analysis, and protein structure. Genome biology, 24(1), 249.

  • Pertea, M., Shumate, A., Pertea, G., Varabyou, A., Breitwieser, F. P., Chang, Y. C., ... & Salzberg, S. L. (2018). CHESS: a new human gene catalog curated from thousands of large-scale RNA sequencing experiments reveals extensive transcriptional noise. Genome biology, 19(1), 1-14.
  • Contact

    The CHESS project is led by Mihaela Pertea, Steven Salzberg and Ales Varabyou at Johns Hopkins university.

    Issues

    Please submit your comments and any issues you encounter when using Chess annotation HERE

    Previous Website

    The previous version of this webpage can be accessed at: https://ccb.jhu.edu/chess_backup_08102022/index.shtml.