CHESS

CHESS is a comprehensive set of human genes based on nearly 10,000 RNA sequencing experiments produced by the GTEx project. It includes a total of

protein-coding genes and

lncRNA genes. Adding antisense and other RNA genes, release

of the database contains

genes and

transcripts. Of these transcripts,

represent protein-coding gene isoforms and the rest are noncoding RNAs. The database also contains

pseudogenes and

corresponding transcripts as well as

genes and

transcripts annotated on alternative scaffolds of GRCh38.

CHESS data

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Publications

Varabyou, A., Sommer, M. J., Erdogdu, B., Shinder, I., Minkin, I., ... & Pertea, M. (2022). CHESS 3: an improved, comprehensive catalog of human genes and transcripts based on large-scale expression data, phylogenetic analysis, and protein structure. Genome biology, 24(1), 249.

Pertea, M., Shumate, A., Pertea, G., Varabyou, A., Breitwieser, F. P., Chang, Y. C., ... & Salzberg, S. L. (2018). CHESS: a new human gene catalog curated from thousands of large-scale RNA sequencing experiments reveals extensive transcriptional noise. Genome biology, 19(1), 1-14.

Contact

The CHESS project is led by Mihaela Pertea, Steven Salzberg and Ales Varabyou at Johns Hopkins university.

Issues

Please submit your comments and any issues you encounter when using Chess annotation HERE

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