Ela photo

Mihaela Pertea

Associate Professor

Institute of Genetic Medicine

Johns Hopkins University School of Medicine

Welch Medical Library, 1900 E. Monument St., Rm 109
Baltimore, MD 21205

Phone: (443) 287-0972    E-mail: mpertea jhu edu

Selected publications

  1. Pertea M, Shumate A, Pertea G, Varabyou A, Breitwieser FP, Chang YC, Madugundu AK, Pandey A and Salzberg SL. CHESS: a new human gene catalog curated from thousands of large-scale RNA sequencing experiments reveals extensive transcriptional noise, Genome Biology, 2018, 19:208, doi.org/10.1186/s13059-018-1590-2
  2. Pertea M, Kim D, Pertea GM, Leek JT, Salzberg SL. Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown, Nature Protocols 11, 1650-1667 (2016), doi:10.1038/nprot.2016.095
  3. Chang TC, Pertea M, Lee S, Salzberg SL, Mendell J. Genome-wide annotation of microRNA primary transcript structures reveals novel regulatory mechanisms, Genome Research 2015, Sep;25(9):1401-9. doi: 10.1101/gr.193607.115.
  4. Pertea M, Pertea GM, Antonescu CM, Chang TC, Mendell JT & Salzberg SL. StringTie enables improved reconstruction of a transcriptome from RNA-seq reads, Nature Biotechnology 2015, doi:10.1038/nbt.3122
  5. Deng K, Pertea M, Rongvaux A, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Kumar P, Deeks SG, Siliciano JD, Salzberg SL, Flavell RA, Shan L & Siliciano RF. Broad-spectrum CTL response is required to clear latent HIV-1 due to dominance of escape mutations, NATURE 2015, 517 (7534), 381-385.
  6. Salzberg SL, Pertea M, Fahrner JA, Sobreira N. DIAMUND: Direct Comparison of Genomes to Detect Mutations, Human Mutation 2014, 35:283288
  7. Pertea M The Human Transcriptome: An Unfinished Story, Genes 2012, 3(3), 344-360
  8. Pertea M, Pertea GM, Salzberg SL. Detection of lineage-specific evolutionary changes among primate species, BMC Bioinformatics 2011, 12: 274
  9. Salzberg SL & Pertea M. Do-it-yourself genetic testing. Genome Biology 2010, 11:404
  10. Pertea M, Salzberg SL. Between a chicken and a grape: estimating the number of human genes. Genome Biol. 2010 May 5;11(5):206
  11. Pertea, M, Ayanbule, K; Smedinghoff, M, Salzberg SL. OperonDB: a comprehensive database of predicted operons in microbial genomes. NUCLEIC ACIDS RESEARCH 2009, 37: D479-D482
  12. Haas, BJ, Salzberg, SL, Zhu, W, Pertea M, Allen JE, Orvis J, White O, Buell CR, Wortman JR. Automated eukaryotic gene structure annotation using EVidenceModeler and the program to assemble spliced alignments. GENOME BIOLOGY 2008, 9(1):R7
  13. Pertea, M, Salzberg, SL. "Using protein domains to improve the accuracy of ab initio gene finding." LECTURE NOTES IN COMPUTER SCIENCE, 7th International Workshop, WABI 2007 Proceedings, Vol 4645: 208-215
  14. Pertea, M; Mount, SM; Salzberg, SL A computational survey of candidate exonic splicing enhancer motifs in the model plant Arabidopsis thaliana. BMC BIOINFORMATICS 8(159)
  15. Allen, JE, Majoros, WH, Pertea, M, Salzberg SL. JIGSAW, GeneZilla, and GlimmerHMM: puzzling out the features of human genes in the ENCODE regions. GENOME BIOLOGY 7(S9): 1-13
  16. Majoros WH, Pertea M, Salzberg SL. Efficient implementation of a generalized pair hidden Markov model for comparative gene finding, BIOINFORMATICS 2005 May 1;21(9):1782-8
  17. Majoros WH, Pertea M, Delcher AL, Salzberg SL. Efficient decoding algorithms for generalized hidden Markov model gene finders, BMC BIOINFORMATICS, 2005 Jan 24;6(1):16
  18. Majoros WH, Pertea M, and Salzberg SL, TigrScan and GlimmerHMM: two open-source ab initio eukaryotic gene-finders, BIOINFORMATICS 2004, 20(16):2878-9
  19. Allen JE, Pertea M, Salzberg SL, Computational gene prediction using multiple sources of evidence, GENOME RES 14 (1): 142-148
  20. Carlton JM, Angiuoli SV, Suh BB, Kooij TW, Pertea M, Silva JC, et al. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii, NATURE 419 (6906): 512-519
  21. Pertea M, Salzberg SL, "A method to improve the performance of translation start site detection and its application for gene finding", LECTURE NOTES IN COMPUTER SCIENCE, Second International Workshop, WABI 2002 Proceedings, Vol 2452: 210-219
  22. Pertea M. and Salzberg S.L. Computational gene finding in plants. PLANT MOLECULAR BIOLOGY. 2002 48(1-2):39-48
  23. Yuan Q, Quackenbush J, Sultana R, Pertea M, Salzberg SL, Buell CR. Rice bioinformatics. analysis of rice sequence data and leveraging the data to other plant species, PLANT PHYSIOL. 2001 Mar;125(3):1166-74
  24. Pertea M, Lin X, Salzberg SL. GeneSplicer: a new computational method for splice site prediction, NUCLEIC ACIDS RES. 2001 Mar 1; 29(5):1185-90
  25. Pertea M, Salzberg SL, Gardner MJ, Finding genes in Plasmodium falciparum,NATURE, 2000 Mar 2;404(6773):34
  26. Salzberg SL, Pertea M, Delcher AL, Gardner MJ, Tettelin H, Interpolated Markov models for eukaryotic gene finding, GENOMICS. 1999 Jul 1;59(1):24-31.

A full list of my published work can be found at Google Scholar.


Work supported in part by NSF award DBI-1458178 and NSF award DBI-1759518.