The Center for Computational Biology

A joint research center in the McKusick-Nathans Institute of Genetic Medicine, spanning the School of Medicine, the Whiting School of Engineering, the Bloomberg School of Public Health, and the Krieger School of Arts & Sciences

The Center for Computational Biology (CCB) is a multidisciplinary center dedicated to research on genomics, genetics, DNA sequencing technology, and computational methods for DNA and RNA sequence analysis. CCB brings together scientists and engineers from many fields, including computer science, biostatistics, genomics, genetics, molecular biology, physics, and mathematics, all of whom share a common interest in gaining a better understanding of how genes and genomes affect biological functions. We develop and apply technology that uses sequence data to study a wide range of questions, including how genes cause disease, how genes change in response to different conditions within the cell, and how genomes evolve.

Computational scientists in CCB develop novel software methods for analysis of sequencing data deriving from many different types of sequencing experiments, including:

  • whole genome sequencing and assembly
  • transcriptome sequencing (RNA-seq)
  • microbiome sequencing and analysis
  • human re-sequencing
  • methylation analysis (Methyl-seq)
  • exome sequencing

In addition to its research program, CCB provides bioinformatics expertise to departments and centers throughout the Schools of Medicine and Public Health, through a consulting group trained in the latest computational methods. CCB provides the computing hardware for the analyses run through its consulting group.

CCB is organized as a research center within the McKusick-Nathans Institute of Genetic Medicine, an interdisciplinary research institute supporting genetics and genomics research at the Johns Hopkins School of Medicine. The Center is also affiliated with the Department of Computer Science> in the Whiting School of Engineering, the Department of Biostatistics in the Bloomberg School of Public Health, and the Department of Biomedical Engineering in the Schools of Medicine and Engineering. Members of the Center include faculty in the JHU School of Medicine, the Bloomberg School of Public Health, the Whiting School of Engineering, and the Zanvyl Krieger School of Arts & Sciences.

CCB has a high-performance computing facility operated jointly with the Institute for Data-Intensive Engineering and Science (IDIES), a JHU institute supporting scientific research ranging from medicine to astrophysics. The CCB computing facility includes large-scale data storage devices, large-memory compute servers, and a computing grid with thousands of processors.

Directions

As of September 2014, CCB is headquartered in the Welch Medical Library, 1900 E. Monument St., Baltimore, MD 21205.

For a visitor map of the Johns Hopkins Medical Campus, please see this link.