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Combining DNA and protein alignments to improve genome annotation with LiftOn
LiftOn documentation
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  • Installation
  • Quick Start Guide

Examples

  • Same species lift-over
    • Human (GRCh38 to T2T-CHM13)
    • Mouse
    • Honey bee
    • Thale cress
    • Rice
  • Closely related species lift-over
    • Human (GRCh38) to Chimpanzee
  • Distantly related species lift-over
    • Drosophila melanogaster to Drosophila erecta
    • Mouse to Rat

Info

  • Output files
  • bigBed conversion
  • Gene / Transcript counting
  • Evaluation metrics - sequence identity
  • Behind the scenes
  • FAQ ...
  • User Manual
  • Changelog
  • License
  • Contact
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Closely related species lift-over#

When you intend to annotate your recently assembled genome and find that there is no pre-annotated reference for the same species or that a closely related species has significantly better annotations than your assembled species, you can use LiftOn to transfer annotations between the two species.

LiftOn is particularly effective in mapping annotation between closely-related species. Here is an example of using LiftOn to transfer annotations from Homo sapiens GRCh38 to Pan troglodytes (chimpanzee).


LiftOn examples

  • Human (GRCh38) to Chimpanzee






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